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My research interests primarily pertain to the identification of novel inhibitors against Mycobacterium tuberculosis, the causative agent of tuberculosis, which can be developed into potent drugs against TB. Also, the research efforts are dedicated towards the understanding of host-pathogen interactions involved in TB pathogenesis. The work specifically is focused on the high throughput screening of various small molecule libraries against the growth of Mycobacterium tuberculosis by employing a rapid and robust strategy resazurin dye based cell screening assay. Subsequently, various assays are performed to check the drug likeness and selectivity index of the shortlisted compounds. Following this, all the hits are then evaluated for their ability to inhibit the intracellular survival of the pathogen which is performed by a fluorescence based method for screening of intraphagosomal growth of M.tuberculosis. Moreover, promising inhibitors are then evaluated in mice model of tuberculosis to check the efficacy of the compounds towards the treatment of the disease.

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